A drill sergeant (Sasha Roiz) at a camp for troubled kids collapses with severe back pain, and House and the team must find a connection when one of his recruits (Tyler James Williams) falls ill with the same symptoms. Meanwhile, Chase must track down whoever is pranking him through a social networking site, and House [...]

When a bassist (Matthew Lillard) passes out after saving a woman in a subway station, the team must treat him amidst his newfound celebrity, while he begins to realize he may be a better man than he believed. Meanwhile, House must survive a dinner with Cuddy’s mother (Candice Bergen), and Taub comes to terms with [...]

House must battle disease as well as belief when his patient (Kuno Becker) gets sick after crucifying himself as part of a bargain with God to keep his daughter cancer-free. But when this bargain causes him to refuse treatment, House must devise a new tactic. Meanwhile, Taub sees the other side of indiscretion, and Wilson [...]

A teenage girl (Hayley Chase) comes to the hospital displaying classic smallpox symptoms, which the team dismisses as impossible until her step-father (Andrew Fiscella) gets sick as well. Once the CDC intervenes and isolates the patients, the team is unable to explore any further until House takes a life-threatening risk.

Brilliant medical student Martha M. Masters (Amber Tamblyn) joins the team at Cuddy’s insistence, and her first case is treating a campaign manager (Jack Coleman) who falls ill with a rash, leading to liver failure. But Masters’ morality puts her at odds with House and the rest of his team. Meanwhile, House debates whether it’s [...]

When a newborn experiences breathing problems, the team must look at her mother’s (Jennifer Grey) medical history for clues, and what they find leads the mother to a difficult decision. Meanwhile, Foreman and Taub must both find a female replacement for Thirteen, and House and Wilson learn valuable lessons in babysitting when Cuddy has to [...]

House and the team treat a woman (Erin Cahill) suffering from severe vomiting, heart problems, and a fever, but in the course of treatment, the team discovers that she is not who she says she is. During the case, House’s new fellow (Vinessa Shaw), a psychiatrist that Chase hired, is welcomed with a trial by [...]

House and his team race against time to help an author (Amy Irving) who suffered a seizure while attempting to kill herself. With time running out until her psychiatric hold is over and she is released, House believes a clue may be found in her newest manuscript. Meanwhile, House tries to find what common interests [...]

The team treats a teen skateboarder (Alyson Stoner) who collapsed during a competition, and her family must make an impossible decision. Meanwhile, House reveals his relationship with Cuddy to his team, and they both worry whether they can keep their work lives and love lives separate.

House and Cuddy take the day off to talk about their new relationship, while the team tries to cure the lone neurosurgeon (George Wyner) on staff who must be ready to operate. If not, the hospital will have to shut down its ER and ICU. During the case, Thirteen prepares for her leave of absence.